Boron neutron capture therapy of intracerebral rat gliosarcomas.
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چکیده
منابع مشابه
Boron Neutron Capture Therapy
A project aimed at the development of an accelerator facility devoted to Boron Neutron Capture Therapy (BNCT) is ongoing at the National Atomic Energy Commission of Argentina [1]. In a first stage of development, the accelerator will be capable of delivering proton or deuteron beams of 30 mA at about 1.4 MeV which is suitable for neutron production through the 9Be(d,n) reaction. In this context...
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A rat brain tumor model has been developed utilizing nude rats and the human melanoma cell line MRA 27. For pharmacokinetic and tissue distribution studies, 2 10(5) MRA 27 cells were implanted intracerebrally (i.c.), and 30 days later, 120 mg of 10B-enriched L-boronophenylalanine were injected i.p. into nude rats. 10B concentrations in the tumor, blood, and normal brain were 23.7, 9.4, and 8.4 ...
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A rat brain tumor model has been developed utilizing nude rats and the human melanoma cell line MRA 27. For pharmacokinetic and tissue distribution studies, 2 IO5MRA 27 cells were implanted intracerebrally (i.e.), and 30 days later, 120 mg of '°B-enriched L-boronophenylalanine were injected i.p. into nude rats. '"It concentrations in the tumor, blood, and normal brain were 23.7, 9.4, and 8.4 u...
متن کاملشبیه سازی چشمه 7li(p,n)7be جهت استفاده در bnct (boron neutron capture therapy)
با توجه به اینکه امروزه بیماران بسیاری در سراسر جهان از سرطان رنج میبرند،دانشمندان در تلاشند روشهای درمانی جدیدتر و بهتری را کشف کنند .یکی از این روشها "درمان بوسیله گیراندازی نوترون توسط بور (bnct)" نام دارد که میتواند یکی از بهترین روشهای مفید و موثر و جایگزین در درمان سرطانهایی از نوع glioblastoma و melanoma نسبت به روشهای متداولی چون شیمی درمانی یا رادیوتراپی باشد.در این روش هدف انجام واکنش...
Boron Neutron Capture Therapy of Cancer1
brain tumors. Shortly thereafter, a clinical trial was initiated at the Brookhaven National Laboratory in cooperation with Sweet and others at the Massachusetts General Hospital utilizing borax as the capture agent (5, 6). The objective at that time was to use BNCT as an adjunct to surgery for the treatment of patients with the most highly malignant and therapeutically refractory of all brain t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.24.9808